DETAILED NOTES ON B220

mitotane will decrease the extent or influence of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers lowers plasma concentration of abemaciclib and its metabolites.Dato-Dxd didn't create severe toxicity at doses as many as two hundred mg/kg